Mechanism of Action
NAD+ (Nicotinamide Adenine Dinucleotide) is a crucial coenzyme found in every living cell, playing a vital role in numerous biochemical processes. It exists in two main forms: NAD+ (oxidized) and NADH (reduced), switching between these forms as it participates in redox reactions.
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Energy Metabolism:NAD+ is essential for cellular energy production. It acts as a coenzyme in metabolic pathways such as glycolysis, the TCA cycle, oxidative phosphorylation (OXPHOS), fatty acid oxidation (FAO), and alcohol metabolism. For instance, in glycolysis, NAD+ facilitates reactions catalyzed by glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and lactate dehydrogenase (LDH), helping convert glucose into pyruvate and ultimately ATP.
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Gene Expression Regulation:NAD+ influences gene expression through its role as a co-substrate for enzymes like sirtuins and PARPs (poly(ADP-ribose) polymerases). Sirtuins, which are NAD+-dependent deacetylases, remove acetyl groups from histones, affecting chromatin structure and gene activity. PARPs use NAD+ to add ADP-ribose groups to proteins, aiding in DNA repair and genomic stability.
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Circadian Rhythm:NAD+ levels fluctuate throughout the day, influencing the body's internal clock. This circadian oscillation helps synchronize various biological processes, including sleep, hormone production, and metabolism. The NAD+/NADH ratio modulates the activity of core clock proteins like CLOCK and BMAL1, which control the expression of circadian genes.
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DNA Repair:In response to DNA damage, PARPs consume NAD+ to initiate repair mechanisms. This process is crucial for maintaining genomic stability and preventing cellular damage over time. Sufficient NAD+ levels are necessary for these repair enzymes to function effectively.
Functions
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Energy Production:NAD+ helps convert nutrients from food into ATP, the energy currency of the cell. It is involved in the mitochondrial electron transport chain, where NADH donates electrons to produce ATP.
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Anti-Aging Effects:NAD+ levels decline with age, contributing to aging-related issues like mitochondrial dysfunction and oxidative stress. Boosting NAD+ levels has been shown to improve energy metabolism, muscle function, and lifespan in animal studies.
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Neuroprotection:NAD+ supports neuronal health by maintaining mitochondrial function and facilitating DNA repair. It is essential for cognitive function and may help mitigate neurodegenerative diseases.
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Immune Support:NAD+ plays a role in immune cell function and the regulation of inflammatory responses. It helps maintain immune system efficiency and resilience.
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Metabolic Regulation:NAD+ is involved in metabolic flexibility, the ability to switch between using carbohydrates and fats for energy. This is important for maintaining healthy blood sugar levels and body weight.
Usage Guidelines
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Dosage:The recommended dosage of NAD+ supplements can vary. For general health maintenance, doses ranging from 100 to 500 mg per day are common. However, individual needs may differ, and it is advisable to consult a healthcare provider for personalized recommendations.
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Formulations:NAD+ supplements are available in various forms, including capsules, tablets, and sublingual sprays. The choice of formulation may depend on personal preference and the specific product's bioavailability.
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Timing:NAD+ supplements can be taken at any time of the day. Some people prefer to take them in the morning to support energy levels throughout the day, while others may take them before bedtime to aid sleep and recovery.
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Monitoring:It is important to monitor how your body responds to NAD+ supplementation. Pay attention to any changes in energy levels, sleep quality, and overall well-being. If you experience any adverse effects, consult a healthcare professional
Product Name |
NAD+ Injection |
Active Ingredient |
NAD+ Injection |
Dosage Form |
Injection |
Strength |
1000mg/vial |
Packaging |
10vials/Box Customizable version |
Manufacturer |
Sinopharmatech Co., Ltd. |
Storage Conditions
• Store in a refrigerated environment at 2°C-8°C, away from light
• Short-term transportation is possible at 15°C-25°C but should not exceed seven days
• Inspect the solution before use to ensure it is clear and free from particles or discoloration






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High Purity (≥98%)
Flexible Dosing Options
GMP-Certified Quality
Weekly Dosing for Convenience