Mechanism of Action
Ipamorelin is a synthetic pentapeptide classified as a growth hormone secretagogue (GHS). It functions by selectively activating the gh*re*lin receptor (GHSR-1a), which is widely distributed in the brain and other tissues such as the gastrointestinal tract, heart, lung, liver, kidney, pancreas, adipose tissue, and immune cells. This selective activation leads to the release of growth hormone (GH) from the anterior pituitary gland without significantly affecting other hormones like adrenocorticotropic hormone (ACTH) or cortisol.
The mechanism of action can be summarized as follows:
- Receptor Targeting: Ipamorelin binds to the gh*re*lin receptor (GHSR-1a) in the brain, mimicking the action of the natural hormone gh*re*lin.
- Pituitary Activation: This binding stimulates the somatotroph cells in the anterior pituitary gland to release growth hormone (GH).
- Hypothalamic Influence: Ipamorelin may also enhance the effects of Gro*wth hor*mone-rel*eas*ing hor*mone (GH*RH) by working at the hypothalamus to increase GH*RH and/or decrease somatostatin.
- Selective Action: Unlike other GHRPs (e.g., G*H*R*P*-2 and GH*RP-6), Ipamorelin does not significantly increase ACTH or cortisol levels, making it highly selective for GH release.
This selective mechanism of action makes Ipamorelin a valuable tool for researchers studying GH regulation and its effects on various physiological systems.
Effects
Ipamorelin has been shown to have several beneficial effects, particularly in the context of mus*cle gro*wth, fat loss, and overall health. Here are some of the key effects:
- Mus*cle gro*wth and Repair: Ipamorelin increases protein synthesis and amino acid utilization, leading to enhanced muscle development and recovery.
- Fat Loss: Elevated GH levels improve body composition by increasing the metabolism of stored fat, particularly targeting stubborn abdominal fat.
- Bone Health: Ipamorelin stimulates osteoblast activity, calcium retention, and collagen production, contributing to improved bone density and skeletal health.
- Metabolic Rate: The peptide enhances metabolic rate through increased muscle mass and improved glucose regulation.
- Sleep Quality: Some users report improved sleep patterns after Ipamorelin administration, which can support recovery and hormone balance.
- Anti-Aging: By promoting collagen production and maintaining muscle mass, Ipamorelin can contribute to overall vitality and a youthful appearance.
Dosage Instructions
Ipamorelin is typically administered via subcutaneous injection. The dosage and frequency can vary depending on the individual's goals and medical advice. Here are general guidelines:
- Dosage: The recommended daily dosage ranges from 100 to 300 micrograms (µg), divided into one to two injections per day. For example:
- 100 µg once daily: Suitable for beginners or those looking for a mild effect.
- 200 µg once daily: A moderate dose for most users.
- 300 µg once or twice daily: For more significant effects, especially when combined with other peptides like CJC-1295 DAC.
- Injection Timing: It is best to administer Ipamorelin on an empty stomach, either in the morning or before bedtime, to maximize GH release. Avoiding food for at least 30 minutes before and after injection can enhance the peptide's effectiveness.
- Cycle Length: A typical treatment cycle lasts 4 to 12 weeks. Shorter cycles (4-6 weeks) are often used for initial assessment, while longer cycles (8-12 weeks) may be necessary for more pronounced effects.
- Injection Technique:
- Clean the vial rubber stopper and injection site with an alcohol swab.
- Insert the needle at a 45-90° angle into the subcutaneous tissue.
- Inject slowly and rotate injection sites (e.g., abdomen, thigh) to minimize tissue stress.
Important Considerations
- Monitoring and Safety: Regular monitoring for unusual reactions is essential. Discontinue use and consult a healthcare professional if side effects such as injection-site irritation, headache, or increased appetite occur.
- Lifestyle Factors: To maximize the benefits of Ipamorelin, maintain a balanced diet with adequate protein intake, engage in regular strength training and cardiovascular exercise, and ensure sufficient sleep and stress management.
- Combination Therapy: Ipamorelin can be combined with other peptides like CJC-1295 DAC for a synergistic effect on GH and IGF-1 levels. However, it is crucial to follow specific protocols and use separate syringes for each peptide.
| Product Name |
Ipamorelin |
| Active Ingredient |
Ipamorelin |
| Dosage Form |
Granules |
| Strength |
10mg/vial |
| Packaging |
10vials/Box Customizable version |
| Manufacturer |
Sinopharmatech Co., Ltd. |
Storage Conditions
• Store in a refrigerated environment at 2°C-8°C, away from light
• Short-term transportation is possible at 15°C-25°C but should not exceed seven days
• Inspect the solution before use to ensure it is clear and free from particles or discoloration
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High Purity (≥98%)
Flexible Dosing Options
GMP-Certified Quality
Weekly Dosing for Convenience
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