Mechanism of Action
M*O*T*S*-C* (Mitochondrial Open-Reading-Frame of the Twelve S rRNA Type-C) is a peptide composed of 16 amino acids encoded by the mitochondrial genome. It plays a crucial role in cellular metabolism and stress response through several mechanisms:
- Nuclear Gene Expression Regulation:
- Under metabolic stress conditions, M*O*T*S*-C* can translocate to the cell nucleus and bind to transcription factors, modulating the expression of nuclear genes. This enhances the cell's ability to resist stress.
- AMPK Pathway Activation:
- M*O*T*S*-C* regulates the folate cycle and purine biosynthesis pathways, increasing AICAR levels, which in turn activates AMPK. AMPK is an energy-sensing enzyme that regulates energy balance and has anti-inflammatory effects.
- SIRT1/PGC-1α Pathway:
- M*O*T*S*-C* promotes the expression of PGC-1α via AMPK, which regulates mitochondrial biogenesis and function. This enhances the cell's antioxidant capacity and metabolic regulation.
- NF-κB Pathway Inhibition:
- M*O*T*S*-C* reduces the production of reactive oxygen species (ROS) and inhibits the NF-κB pathway, leading to decreased levels of pro-inflammatory cytokines and exerting anti-inflammatory effects.
Uses
M*O*T*S*-C* has a wide range of physiological and pathological roles:
- Metabolic Regulation:
- Improving Insulin Sensitivity: M*O*T*S*-C* enhances insulin sensitivity by modulating metabolic pathways, improving glucose uptake and utilization.
- Regulating Fat Oxidation: M*O*T*S*-C* promotes fatty acid oxidation, reducing fat accumulation and helping to control weight and obesity.
- Anti-inflammatory and Antioxidant Effects:
- Inhibiting Inflammatory Responses: By inhibiting the NF-κB pathway, M*O*T*S*-C* reduces the production of pro-inflammatory cytokines, alleviating inflammation.
- Antioxidant Effects: M*O*T*S*-C* decreases ROS production and enhances the cell's antioxidant defense mechanisms.
- Anti-aging and Longevity:
- Enhancing Cellular Stress Response: M*O*T*S*-C* enhances the cell's stress response capabilities by modulating nuclear gene expression and activating the AMPK pathway, delaying cellular aging.
- Extending Lifespan: In model organisms, high levels of M*O*T*S*-C* expression are associated with extended lifespan.
- Exercise Mimicry:
- Enhancing Physical Strength and Endurance: M*O*T*S*-C* is considered an "exercise mimetic" peptide that optimizes energy utilization and metabolic pathways, improving physical performance.
- Cardiovascular Protection:
- Protecting Coronary Artery Endothelial Cells: M*O*T*S*-C* can protect the function of coronary artery endothelial cells by inhibiting oxidative stress and inflammatory responses.
Dosage Instructions
- Laboratory Research:
- In cell culture and animal models, the dosage of M*O*T*S*-C* typically varies depending on the experimental design and target tissue. For example, in mouse models, the dosage range of M*O*T*S*-C* can vary from a few micrograms to tens of micrograms.
- Future Clinical Applications:
- Given its metabolic regulation and anti-inflammatory properties, M*O*T*S*-C* holds promise for treating metabolic diseases (such as diabetes and obesity), cardiovascular diseases, and inflammatory conditions. However, specific clinical dosages and administration protocols will need to be determined through further clinical trials.
Summary
M*O*T*S*-C* is a mitochondrial-derived peptide with a wide range of physiological functions. Through its mechanisms of regulating metabolism, anti-inflammatory and antioxidant effects, it shows potential in the treatment of various diseases.
Product Name |
M*O*T*S*-C* |
Active Ingredient |
M*O*T*S*-C* |
Dosage Form |
Injection |
Strength |
30mg/vial |
Packaging |
10vials/Box Customizable version |
Manufacturer |
Sinopharmatech Co., Ltd. |
Storage Conditions
• Store in a refrigerated environment at 2°C-8°C, away from light
• Short-term transportation is possible at 15°C-25°C but should not exceed seven days
• Inspect the solution before use to ensure it is clear and free from particles or discoloration





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