Cortagen: Neuroprotective Peptide for Cognitive Enhancement and Brain Health

• Customization: Available
• Application: Salon
• Disposable: Injection
• Model NO.: SD-G-B-20257
• Gender: Unisex
• Side Effect: Dry Mouth
• Usage: Injection
• Pharmaceutical Technology: Chemical Synthesis
• Efficacy: Neuroprotection
• Health Food Approval No.: Z02
• Transport Package: Ampoule Vial
• Specification: 10mg/vial*10vials
• Origin: Shandong, China
• HS Code: 30049090
• Production Capacity: 5000000 Pieces/Month

Product Description

 

Product Name	Cortagen
Active Ingredient	Cortagen
Dosage Form	Injection
Strength	10mg/vial*10vials
Manufacturer	Sinopharmatech Co., Ltd.

Mechanism of Action

Cortagen is a synthetic peptide designed to modulate neuronal function and protect against neurodegeneration. Its primary mechanisms include:

• Neurotrophic Support: Mimics endogenous neurotrophic factors (e.g., BDNF, NGF) to promote neuronal survival, synaptic plasticity, and axonal growth.
• Anti-Inflammatory Effects: Reduces microglial activation and pro-inflammatory cytokines (e.g., TNF-α, IL-1β), mitigating neuroinflammation-a hallmark of neurodegenerative diseases.
• Antioxidant Activity: Enhances cellular defense systems by upregulating antioxidant enzymes (e.g., superoxide dismutase, glutathione peroxidase), protecting neurons from oxidative stress.
• Neurotransmitter Modulation: Influences acetylcholine and glutamate signaling, improving cognitive processes such as memory and learning.

2. Therapeutic Applications

Current Clinical Uses

1. Neurodegenerative Diseases:
   • Alzheimer's Disease (AD): Slows cognitive decline by reducing amyloid-beta toxicity and preserving cholinergic neurons.
   • Parkinson's Disease (PD): Protects dopaminergic neurons in the substantia nigra, potentially alleviating motor symptoms.
2. Stroke Recovery: Promotes neurogenesis and angiogenesis in ischemic brain regions, improving functional outcomes.
3. Traumatic Brain Injury (TBI): Accelerates neuronal repair and reduces apoptosis through neurotrophic signaling.
4. Cognitive Enhancement: Used off-label to improve focus, memory, and mental clarity in healthy adults.

Emerging Research Directions

• Multiple Sclerosis (MS): Investigated for its potential to support remyelination and modulate autoimmune responses.
• Depression and Anxiety: Early studies suggest mood-stabilizing effects via serotonin and dopamine pathway regulation.
• Age-Related Cognitive Decline: Explored as a preventive therapy for mild cognitive impairment (MCI).

3. Future Prospects

Cortagen represents a promising frontier in peptide-based therapeutics. Its ability to target multiple pathological pathways (neuroinflammation, oxidative stress, synaptic dysfunction) positions it as a versatile agent for:

• Personalized Medicine: Tailored dosing based on genetic profiles (e.g., APOE4 carriers in AD).
• Combination Therapies: Synergistic use with cholinesterase inhibitors (e.g., donepezil) or NMDA receptor antagonists (e.g., memantine).
• Global Market Expansion: Regulatory approvals in Europe and Asia could drive adoption for neurodegenerative diseases.

4. Dosage and Administration

Standard Protocols

• Route: Subcutaneous or intramuscular injection for systemic bioavailability.
• Dosing:
  • Neurodegenerative Diseases: 5-10 mg/day for 4-6 weeks, followed by maintenance cycles (e.g., 5 mg/day, 3 times weekly).
  • Stroke/TBI: 10-20 mg/day for 2-3 weeks post-injury.
  • Cognitive Enhancement: 2-5 mg/day for 10-14 days, repeated monthly.
• Cycling: Typically administered in 4-6 week cycles with 2-4 week breaks to prevent receptor desensitization.

Individualization

• Elderly Patients: Lower initial doses (e.g., 2 mg/day) to minimize side effects.
• Combination Use: Often paired with antioxidants (e.g., CoQ10) or omega-3 fatty acids for enhanced neuroprotection.

5. Storage and Stability

• Lyophilized Powder: Store at 2-8°C (36-46°F); stable for up to 2 years.
• Reconstituted Solution: Use within 24 hours if refrigerated (2-8°C); discard if cloudy or discolored.
• Avoid Freezing: Freezing may degrade peptide structure, reducing efficacy.

6. Safety and Considerations

• Side Effects: Generally well-tolerated; mild reactions include injection-site redness or transient headaches.
• Contraindications: Hypersensitivity to peptide components, active malignancy, or severe renal/hepatic impairment.
• Monitoring: Regular cognitive assessments and inflammatory markers (e.g., CRP) during long-term use.

7. Conclusion

Cortagen's multimodal mechanism and broad therapeutic potential make it a compelling candidate for neurodegenerative diseases and cognitive enhancement. While clinical validation is ongoing, its ability to address root causes of neuronal dysfunction (inflammation, oxidative stress) sets it apart from traditional symptomatic treatments. Future research should focus on large-scale trials, optimal dosing strategies, and long-term safety profiling to unlock its full clinical potential.

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