Mechanism of Action
Melanotan II (MT-II) is a synthetic analog of the naturally occurring hormone alpha-melanocyte-stimulating hormone (α-MSH). It acts as a non-selective agonist of the melanocortin receptors MC1, MC3, MC4, and MC5. The primary mechanism of action involves the activation of the melanocortin 1 receptor (MC1R) in melanocytes, which leads to increased melanin production and subsequent skin darkening. This process mimics the natural tanning response to UV exposure but does not require prolonged sun exposure, thereby reducing the risk of UV-induced skin damage.
In addition to its effects on melanogenesis, Melanotan II also interacts with other melanocortin receptors. Activation of the melanocortin 4 receptor (MC4R) is thought to be responsible for the peptide's effects on sexual function and appetite regulation. These off-target interactions explain some of the secondary effects observed with Melanotan II use, such as increased libido and appetite suppression.
Uses
Melanotan II is primarily used for its tanning effects, providing a deeper and more even skin pigmentation without the need for excessive UV exposure. This makes it a popular choice for individuals seeking a sunless tan, particularly those with fair skin or a high risk of melanoma. Beyond cosmetic use, Melanotan II has been studied for its potential benefits in several medical contexts:
-
Photoprotection: By increasing melanin levels, Melanotan II offers a natural protective effect against UV radiation, potentially reducing the risk of sunburn and skin cancer.
-
Sexual Dysfunction: Research has shown that Melanotan II can be effective in treating certain types of sexual dysfunction, including erectile dysfunction.
-
Appetite Regulation: Some users experience a decrease in appetite, which can aid in weight management.
-
Mood Enhancement: The peptide may have mood-enhancing effects due to its action on the central nervous system.
Dosage Instructions
The dosage of Melanotan II can vary depending on individual goals and tolerance. Here is a general guideline for its use:
-
Initial Dosing:
-
Loading Phase:
-
During the first 1-2 weeks, administer 250 mcg daily.
-
Gradually increase the dose to 500 mcg for weeks 3-4, and then to 1 mg for weeks 5-6.
-
Maintenance Phase:
-
Reconstitution and Storage:
-
Reconstitute the lyophilized peptide with up to 3 mL of bacteriostatic water to achieve a concentration of approximately 3.33 mg/mL.
-
Store the reconstituted solution in the refrigerator and use within 30 days.
-
Injection Technique:
-
Administer Melanotan II via subcutaneous injection, typically in the abdominal region.
-
Ensure proper hygiene by using sterile syringes and cleaning the injection site.
Product Name |
Melanotan II |
Active Ingredient |
Melanotan II |
Dosage Form |
Injection |
Strength |
5mg/vial |
Packaging |
10vials/Box Customizable version |
Manufacturer |
Sinopharmatech Co., Ltd. |
Storage Conditions
• Store in a refrigerated environment at 2°C-8°C, away from light
• Short-term transportation is possible at 15°C-25°C but should not exceed seven days
• Inspect the solution before use to ensure it is clear and free from particles or discoloration






Support different package method
For more information, please feel free to contact us.
Why Choose Us?
High Purity (≥98%)
Flexible Dosing Options
GMP-Certified Quality
Weekly Dosing for Convenience